Trisomy FISH screen (13,18,21,X,Y), Blood

Test Information

Trisomy Screen FISH analysis is a cytogenetic test used to identify aneuplodies involving chromosomes 13, 18, 21, X, and Y.

Turnaround Time

4 days

CPT Code(s)

Blood: 88230, 88275 x2, 88271 x4, 88291 (Modifier 22) CVS: 88235, 88275 x2, 88271 x4, 88291 (Modifier 22)

Cost

Blood: $1074 CVS: $1372

Indications

The trisomy screen can be used as a rapid initial screen for some of the more common aneuploidies. FISH should be used in conjunction with G-banded chromosome analysis.

Methodology

FISH: Fluorescence in situ hybridization is a molecular cytogenetic technique in which fluorescently labeled DNA probes are hybridized to metaphase spreads or interphase nuclei.

Specimen Requirements

FISH can be performed on any tissue that can be cultured for chromosome analysis, including blood, fibroblasts, amniotic fluid, and chorionic villus sampling. Follow collection and transport guidelines specific for each tissue type. Studies requested should be indicated at the time of sample submission.

Transport Instructions

Blood: Specimen should be kept at room temperature; do not freeze or refrigerate. Specimen should be sent by courier or overnight mail to arrive at the laboratory within 24 hours.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Cytogenetic Testing, FISH
One Mother's Story

One Mother's Story

After a long three-year struggle trying to have children, our son, Charlie, was born on April 18, 2009. He was our miracle...perfect in every way! When Charlie was five days old, our pediatrician called to notify us that one of the numbers from the heel prick test was a bit high. We headed to the hospital that afternoon for more tests. I will never forget the following day. It was cool and crisp - not a cloud in the sky....

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