Steroid Sulfatase Deficiency (STS) : (Xp22.3) FISH Analysis

Test Information

Cytogenetic FISH analysis for Steroid Sulfatase Deficiency (STS) (Xp22.3). FISH is also utilized to confirm microdeletions identified during high resolution chromosome analysis.

Turnaround Time

4 weeks

CPT Code(s)

88275, 88273, 88271 x2, 88291

Cost

$ 710* (does not include culture charge; additional culture charge may apply)


Chromosomes

Xp22.3

Indications

Fluorescence in situ hybridization is a molecular cytogenetic technique in which fluorescently labeled DNA probes are hybridized to metaphase spreads or interphase nuclei. Applications include identification of structurally abnormal chromosomes, including identification of marker chromosomes, detection of very small deletions (microdeletions), and rapid detection of Down syndrome and other numerical chromosome abnormalities; and the rapid detection of sex chromosomes and the SRY gene. FISH should be used in conjunction with G-banded chromosome analysis. FISH is performed upon request when a specific numerical or structural abnormality or microdeletion is suspected. FISH is also utilized to confirm microdeletions identified during high resolution chromosome analysis and to aid in identification of abnormal chromosomes.

Specimen Requirements

FISH can be performed on any tissue that can be cultured for chromosome analysis, including blood, fibroblasts, amniotic fluid, and chorionic villus sampling. Follow collection and transport guidelines specific for each tissue type. Studies requested should be indicated at the time of sample submission.

Transport Instructions

Will vary depending on sample type:
Blood: Specimen should be kept at room temperature; do not freeze or refrigerate. Specimen should be sent by courier or overnight mail to arrive at the laboratory within 24 hours
Amniotic Fluid and CVS: Specimen should be kept at room temperature; do not freeze or refrigerate. Specimen should be sent by courier or overnight mail to arrive at the laboratory within 24 hours.
Solid Tissue(such as skin biopsy, products of conception, or abortus tissue): Specimen should be kept at room temperature if it will be transported immediately. If specimen is not being immediately transported to the laboratory, it may be refrigerated; do not freeze. Specimen should be sent by courier or overnight mail to arrive at the laboratory within 24 hours.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Cytogenetic Testing, FISH
Meet the Shenal Family

Meet the Shenal Family

Our daughter, Ryleigh, was diagnosed with a rare chromosomal deletion shortly after she was born in 2010. Since we received her diagnosis, the Greenwood Genetic Center has become part of our family. They made certain that we did not feel alone, and they continue to provide ongoing, compassionate care for our child. The impact they have had on our family and others across the globe everyday is immeasurable. We can't imagine walking this journey without their...

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