This panel consists of 16 genes associated with various syndromic forms of overgrowth and macrocephaly due to germline mutations. Many of these disorders can present similarly making it difficult to pinpoint the specific diagnosis. Overgrowth may be present in neonates at birth or develop at a later age. In some cases, the patient's growth may normalize as they get older. Additional features for many of the conditions on the panel include intellectual disability, congenital anomalies, or an increased risk for tumors.