Orotic Acid Analysis

Test Information

Orotic acid is a chemical overproduced in an alternative pathway when there is a block in the urea cycle. Excessive amounts of orotic acid are usually found in OTC (ornithine transcarbamylase) deficiency, citrullinemia, and often in argininosuccinic aciduria. Orotic acid determination is useful in delineating the cause of hyperammonemia.

Turnaround Time

10 days

CPT Code(s)

83921

Cost

$100

Indications

Patients with hyperammonemia

Methodology

liquid chromatography-tandem mass spectroscopy (LC-MS/MS)

Specimen Requirements

5 ml of urine is requested. The minimum volume is 1.5 ml. Collect urine in a sterile container and freeze after collection.

Transport Instructions

Urine should be sent frozen on dry ice by courier or 24 hour delivery.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Analyte Analysis, Analytes and Biomarkers, Biochemical Testing
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One Mother's Story

After a long three-year struggle trying to have children, our son, Charlie, was born on April 18, 2009. He was our miracle...perfect in every way! When Charlie was five days old, our pediatrician called to notify us that one of the numbers from the heel prick test was a bit high. We headed to the hospital that afternoon for more tests. I will never forget the following day. It was cool and crisp - not a cloud in the sky....

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