Enzyme activity can be measured in plasma, leukocytes, cultured fibroblasts, or dried blood spots. For plasma and leukocytes, please send 5-10 ml of whole blood in a green top (sodium heparin) tube. Alternatively, plasma can be removed from spun sample and sent frozen.
For dried blood spot collection, a minimum of three circles need to be filled in. Each circle should contain one drop of blood (about 100 microliters). See the link below for additional sample collection and handling instructions.
In addition, a dried blood spot or blood drawn in an EDTA tube can be used for Hunter syndrome molecular analysis and may be sent for DNA banking. Please indicate on the requisition if DNA should be banked for follow-up molecular testing.