Lung Adenocarcinoma : PTEN Mutation Analysis

Test Information

Alterations in PTEN often result in PTEN inactivation and thus increased activity of the PI3K-AKT pathway in neoplastic specimens.

Turnaround Time

5 days

CPT Code(s)

81406

Cost

$350

Genes

Clinical Information

PTEN mutations have been found in 4�8% of all NSCLC and more commonly in smokers and in tumors with squamous cell histology. Somatic mutations of PTEN have been reported in multiple malignancies, including gliomas, melanoma, prostate, endometrial, breast, ovarian, renal, and lung cancers (Lovly, C., L. Horn, W. Pao. 2015. PTEN in Non-Small Cell Lung Cancer (NSCLC). My Cancer Genome https://www.mycancergenome.org/content/disease/lung-cancer/pten/ (Updated June 18).). Identification of PTEN mutations can significantly affect the management of lung cancer patients by allowing them an opportunity to be enrolled in open clinical trials (https://clinicaltrials.gov/show/NCT01884285).

Indications

Gene sequencing and targeted mutation testing and copy number analysis can serve as a useful diagnostic and potentially prognostic tool for the analysis of affected tissues or tumors. The detection of copy number variants or specific gene mutations may enhance treatment decisions.

Specimen Requirements

Analysis can be performed on fresh or frozen tissue samples as well as formalin-fixed, paraffin-embedded tissue samples.

Transport Instructions

The specimen should be kept at the appropriate temperature and delivered via overnight shipping.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Oncology Testing, Targeted Variants
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Meet Makayla Gunn

Makayla was diagnosed with Rett Syndrome in April of 2015 at the age of two.   At about 18 months, we noticed she had started some repetitive hand motions, and her pediatrician was a little concerned that she did not have many words.  She had learned some sign language, and was saying ‘mama’ and ‘dada’, but that was it.  Then she suddenly stopped all of that.  At her 2 year old check-up, the pediatrician referred us to BabyNet, ...

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