Lung Adenocarcinoma : PTEN Mutation Analysis

Test Information

Alterations in PTEN often result in PTEN inactivation and thus increased activity of the PI3K-AKT pathway in neoplastic specimens.

Turnaround Time

5 days

CPT Code(s)

81406

Cost

$350

Genes

Clinical Information

PTEN mutations have been found in 4�8% of all NSCLC and more commonly in smokers and in tumors with squamous cell histology. Somatic mutations of PTEN have been reported in multiple malignancies, including gliomas, melanoma, prostate, endometrial, breast, ovarian, renal, and lung cancers (Lovly, C., L. Horn, W. Pao. 2015. PTEN in Non-Small Cell Lung Cancer (NSCLC). My Cancer Genome https://www.mycancergenome.org/content/disease/lung-cancer/pten/ (Updated June 18).). Identification of PTEN mutations can significantly affect the management of lung cancer patients by allowing them an opportunity to be enrolled in open clinical trials (https://clinicaltrials.gov/show/NCT01884285).

Indications

Gene sequencing and targeted mutation testing and copy number analysis can serve as a useful diagnostic and potentially prognostic tool for the analysis of affected tissues or tumors. The detection of copy number variants or specific gene mutations may enhance treatment decisions.

Specimen Requirements

Analysis can be performed on fresh or frozen tissue samples as well as formalin-fixed, paraffin-embedded tissue samples.

Transport Instructions

The specimen should be kept at the appropriate temperature and delivered via overnight shipping.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Oncology Testing, Targeted Variants
Meet Reggie Roper

Meet Reggie Roper

Reggie has been part of the GGC family for over 18 years. He has short stature, webbing of his hands, pulmonary stenosis, seizures and hydrocephalus along with developmental delay. He carried an initial diagnosis of cardiofaciocutaneous (CFC) syndrome; however, as genetic testing advanced, GGC made the diagnosis of Noonan-like syndrome with loose anagen hair by identifying a mutation in the SHOC2 gene. He is also an active participant in the Greenwood Community Theatre's Penguin Project. "GGC is...

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