Lung Adenocarcinoma : BRAF Mutation analysis (V600E)

Test Information

Turnaround Time

5 days

CPT Code(s)





Clinical Information

BRAF mutations are reported in 1-4% of NSCLC diagnoses. Additionally, the common BRAF V600E mutation occurs in around 55% of BRAF-mutant NSCLC. Increased efficacy of BRAF inhibitors along with phenotypic differences from other common mutations in NSCLC, such as EGFR, has placed increased importance on BRAF mutational status (Therapeutic Advancements in Medical Oncology (2017) 9(1): 46-58). BRAFV600E-mutant NSCLC is more commonly seen in adenocarcinoma and ´┐Żnever smokers´┐Ż and has been associated with poor outcomes and reduced response to platinum-based chemotherapeutic agents. While there have been positive results from treating BRAFV600E-mutant NSCLC with targeted inhibitors, randomized controlled trials are needed to more clearly determine their efficacy (The Lancet Oncology (2016) 17(5): 642-50).


Gene sequencing and targeted mutation testing and copy number analysis can serve as a useful diagnostic and potentially prognostic tool for the analysis of affected tissues or tumors. The detection of copy number variants or specific gene mutations may enhance treatment decisions.

Specimen Requirements

Analysis can be performed on fresh or frozen tissue samples as well as formalin-fixed, paraffin-embedded tissue samples.

Transport Instructions

The specimen should be kept at the appropriate temperature and delivered via overnight shipping.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Oncology Testing, Targeted Variants
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Meet the Shenal Family

Our daughter, Ryleigh, was diagnosed with a rare chromosomal deletion shortly after she was born in 2010. Since we received her diagnosis, the Greenwood Genetic Center has become part of our family. They made certain that we did not feel alone, and they continue to provide ongoing, compassionate care for our child. The impact they have had on our family and others across the globe everyday is immeasurable. We can't imagine walking this journey without their...

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