Lung Adenocarcinoma : BRAF Mutation analysis (V600E)

Test Information

Turnaround Time

5 days

CPT Code(s)

81210

Cost

$350

Genes

Clinical Information

BRAF mutations are reported in 1-4% of NSCLC diagnoses. Additionally, the common BRAF V600E mutation occurs in around 55% of BRAF-mutant NSCLC. Increased efficacy of BRAF inhibitors along with phenotypic differences from other common mutations in NSCLC, such as EGFR, has placed increased importance on BRAF mutational status (Therapeutic Advancements in Medical Oncology (2017) 9(1): 46-58). BRAFV600E-mutant NSCLC is more commonly seen in adenocarcinoma and �never smokers� and has been associated with poor outcomes and reduced response to platinum-based chemotherapeutic agents. While there have been positive results from treating BRAFV600E-mutant NSCLC with targeted inhibitors, randomized controlled trials are needed to more clearly determine their efficacy (The Lancet Oncology (2016) 17(5): 642-50).

Indications

Gene sequencing and targeted mutation testing and copy number analysis can serve as a useful diagnostic and potentially prognostic tool for the analysis of affected tissues or tumors. The detection of copy number variants or specific gene mutations may enhance treatment decisions.

Specimen Requirements

Analysis can be performed on fresh or frozen tissue samples as well as formalin-fixed, paraffin-embedded tissue samples.

Transport Instructions

The specimen should be kept at the appropriate temperature and delivered via overnight shipping.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Oncology Testing, Targeted Variants
Meet Makayla Gunn

Meet Makayla Gunn

Makayla was diagnosed with Rett Syndrome in April of 2015 at the age of two.   At about 18 months, we noticed she had started some repetitive hand motions, and her pediatrician was a little concerned that she did not have many words.  She had learned some sign language, and was saying ‘mama’ and ‘dada’, but that was it.  Then she suddenly stopped all of that.  At her 2 year old check-up, the pediatrician referred us to BabyNet, ...

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