Familial hypertrophic cardiomyopathy (HCM) is associated with the thickening of the cardiac muscle between chambers of the heart. This thickening leads to reduced or inefficient blood flow and can either cause a heart murmur or other symptoms of the condition including chest pain, dyspnea, palpitations, and syncope. Individuals with HCM can also present with sudden death, and this condition has been associated with sudden death in young individuals and athletes. Typically, onset of HCM occurs in adolescence, but it can develop at any age. HCM is primarily inherited in an autosomal dominant manner, but autosomal recessive and X-linked forms occur as well. This panel consists of 24 genes that are associated with this condition.