The panel consists of 14 genes associated with dyskeratosis congenita. This group of conditions is mostly inherited in an autosomal dominant or autosomal recessive pattern, but one gene (DKC1) is inherited as an X-linked recessive disorder. Patients may present with IUGR, failure to thrive, or short stature. Ectodermal features include nail dystrophy, dental anomalies and caries, sparse hair and lashes, premature graying, and skin rashes or pigmentation such as poikiloderma. Leukoplakia, or white patches on mucosal tissue, may be present in some forms of the disorder. Hematologic findings may include anemia, neutropenia, leukopenia, and bone marrow failure or myelodysplastic syndrome. Dilated cardiomyopathy occurs in some types, and gastrointestinal symptoms, kidney abnormalities, and eye findings may be present. Developmental delays may occur, and affected individuals may be at risk for osteoporosis. Recurrent infections are common, and pulmonary fibrosis can occur.