Creatine Kinase Analysis

Test Information

Measurement of serum creatine kinase may be indicated for suspected cases of dystrophinopathies or in patients with muscle injury, pain, or weakness.

Turnaround Time

10 days

CPT Code(s)




Clinical Information

Creatine kinase (CK) is an enzyme found primarily in skeletal muscle, heart muscle, and brain tissue that catalyzes the production and cycling of ATP to produce energy.


Elevated levels of serum creatine kinase may indicate muscle damage or disease such as myocardial infarction, muscular dystrophy, or rhabdomyolysis. Strenuous exercise can also cause mild, temporary increases in CK levels.


Creatine kinase activity is measured via spectrophotometry at a wavelength of 340 nm.

Specimen Requirements

Serum is the preferred specimen. Collect 5-7 ml of peripheral blood in a red-top serum tube, spin down, remove serum, and freeze. Whole blood, collected in a green-top, sodium heparin tube, can be sent at room temperature. Do not freeze whole blood.

Transport Instructions

Serum must be shipped frozen, preferably on dry ice, by overnight delivery services or courier. Whole blood can be shipped overnight at room temperature. Do not freeze whole blood.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Analyte Analysis, Analytes and Biomarkers, Biochemical Testing
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