Congenital contractures are defined by constrictions or rigidity of connective tissues including muscles, ligaments, and tendons resulting in decreased range of motion and stiffness. Contractures occur in numerous genetic disorders, but the features of these syndromes vary greatly and can affect a wide variety of body systems. Treatment is symptomatic and involves physical and occupational therapy, as well as surgical correction when necessary. While over half of these conditions are inherited in an autosomal recessive manner, many phenotypes caused by changes in the same gene have been reported with either dominant or recessive inheritance. In addition, two conditions demonstrate X-linked recessive inheritance.