Colorectal Cancer : KRAS Variant Analysis

Test Information

 

Turnaround Time

5 days

CPT Code(s)

81275 & 81276

Cost

$350

Genes

Clinical Information

Colorectal cancer (CRC) is the fourth most diagnosed cancer and second leading cause of cancer death in the U.S. with 95,270 and 39,220 new cases of colon and rectal cancer projected in 2016, respectively (NCCN, 2017). Additionally, 49,190 people are expected to die from CRC. While EGFR is overexpressed in However, EGFR, the target of these drugs, which is overexpressed in approximately 80% of colorectal carcinomas, failed to predict a therapeutic response to anti-EGFR therapies. KRAS and NRAS genes are the frequently mutated genes downstream of the EGFR signaling pathway, and considered candidate biomarkers for anti-EGFR therapy. These biomarkers have been identified to harbor insensitivity to anti-EGFR therapies with cetuximab and panitumumab.

Indications

Gene sequencing and targeted mutation testing and copy number analysis can serve as a useful diagnostic and potentially prognostic tool for the analysis of affected tissues or tumors. The detection of copy number variants or specific gene mutations may enhance treatment decisions.

Specimen Requirements

Analysis can be performed on fresh or frozen tissue samples as well as formalin-fixed, paraffin-embedded tissue samples.

Transport Instructions

The specimen should be kept at the appropriate temperature and delivered via overnight shipping.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Oncology Testing, Targeted Variants
Meet Makayla Gunn

Meet Makayla Gunn

Makayla was diagnosed with Rett Syndrome in April of 2015 at the age of two.   At about 18 months, we noticed she had started some repetitive hand motions, and her pediatrician was a little concerned that she did not have many words.  She had learned some sign language, and was saying ‘mama’ and ‘dada’, but that was it.  Then she suddenly stopped all of that.  At her 2 year old check-up, the pediatrician referred us to BabyNet, ...

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