This panel consists of 22 genes that have been associated with Coffin-Siris syndrome phenotypes. Features include intellectual disability and developmental delays, failure to thrive, hypotonia, short stature, and joint hyperextensibility. Characteristics facial features include wide mouth with thick lips, bushy brows and long lashes, and a wide and flat nasal bridge. Hirsutism is common although scalp hair is often sparse, and the nails on the fifth digits are typically absent or hypoplastic. Microcephaly may be present, and feeding difficulties are common. Most cases of Coffin-Siris are due to apparently de novo mutations in genes in the SWI-SNF pathway.