Brugada syndrome is associated with ventricular arrhythmias that may result in sudden death in adulthood (SUNDS) or infancy (SIDS). Conduction abnormalities include right bundle branch block, AV block, and sick sinus syndrome. Cardiac arrest may be the first indictaion of this disorder, but other affected individuals experience syncope and ventricular fibrillation with worsening symptoms associated with high fevers. Treatment of affected individuals requires an implanted defibrillator with close monitoring in high-risk situations such as surgery. Brugada syndrome is usually inherited in an autosomal dominant pattern. This panel consists of 18 genes that are associated with this condition.