Brain Tumor : EGFR Amplification Analysis

Test Information

Turnaround Time

10 days

CPT Code(s)

81406

Cost

$1,000

Genes

Disorders

Clinical Information

Frequent copy number changes are also noted in gliomas, particularly those having higher grade malignancies. Gain of chromosome 7 is associated with epidermal growth factor receptor (EGFR) amplification in gliomas. EGFR amplification is reported in GBM at a frequency of 30-40% and is correlated with poor prognosis and increased progression to stage IV disease. Furthermore, EGFR mutations are also reported in gliomas and are associated with EGFR overexpression. EGFR overexpression is typically found without IDH1 mutation in high-grade gliomas. Despite EGFR overexpression in gliomas, treatment with EGFR inhibitors has not produced notable results (Oncotarget (2016) 7(22): 33440-33450).

Indications

Gene sequencing and targeted mutation testing and copy number analysis can serve as a useful diagnostic and potentially prognostic tool for the analysis of affected tissues or tumors. The detection of copy number variants or specific gene mutations may enhance treatment decisions.

Specimen Requirements

Analysis can be performed on fresh or frozen tissue samples as well as formalin-fixed, paraffin-embedded tissue samples.

Transport Instructions

The specimen should be kept at the appropriate temperature and delivered via overnight shipping.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Oncology Testing, Targeted Variants
Meet The Jones Family

Meet The Jones Family

The journey to becoming parents did not start as an easy one for my husband and I. We suffered the heartache of miscarriage and the unimaginable pain of burying our first born child. Our son, sweet 1 lb 1.4 ounce, 12 inches long, teeny, tiny little Joseph “Hamilton” Jones was born with spina bifida, hydrocephalus, and a heart defect. It tore our hearts out leaving the hospital without him, knowing our dreams and hope for the future were shattered. ...

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