Brain Tumor : 1p/19q Co-Deletion Analysis

Test Information

Turnaround Time

10 days

CPT Code(s)

81402

Cost

$500


Chromosomes

1p/19q Co

Disorders

Clinical Information

Loss of heterozygosity (LOH) at 1p19q due to derivative chromosome loss from an unbalanced translocation t(1:19)(q10:p10) is reported to occur with a frequency of ~40% in patients with oligoastrocytoma and 60-80% in oligodendrogliomas. Interestingly, 1p/19q co-deletion is only found in patients with a concomitant alteration in IDH1. Additionally, these patients have been shown to have better prognosis than those having only IDH1 mutated. While this supports the prognostic value of 1p/19q co-deletion, this alteration has also been found to have predictive value in gliomas. Carriers have increased survival compared to non-carriers as well as increased sensitivity to a specific chemotherapeutic regimen (procarbazine, lomustine, and vincristine) (Annals of Translational Medicine (2015) 3(7): 95).

Indications

Gene sequencing and targeted mutation testing and copy number analysis can serve as a useful diagnostic and potentially prognostic tool for the analysis of affected tissues or tumors. The detection of copy number variants or specific gene mutations may enhance treatment decisions.

Specimen Requirements

Analysis can be performed on fresh or frozen tissue samples as well as formalin-fixed, paraffin-embedded tissue samples.

Transport Instructions

The specimen should be kept at the appropriate temperature and delivered via overnight shipping.

Have Questions Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Kellie Walden, MS, CGC

Oncology Testing, Targeted Variants
Meet Makayla Gunn

Meet Makayla Gunn

Makayla was diagnosed with Rett Syndrome in April of 2015 at the age of two.   At about 18 months, we noticed she had started some repetitive hand motions, and her pediatrician was a little concerned that she did not have many words.  She had learned some sign language, and was saying ‘mama’ and ‘dada’, but that was it.  Then she suddenly stopped all of that.  At her 2 year old check-up, the pediatrician referred us to BabyNet, ...

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